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When the Little Sisters of Hoboken discover that their cook, Sister Julia has accidentally poisoned 52 of the sisters, they are in dire need of funds for the burials. The sisters decide the best way to raise money is to put on a variety show. They take over the school auditorium, which is currently set up for the eighth grade production of “Grease.” Meet Reverend Mother Regina, a former circus performer; Sister Mary Hubert, the Mistress of Novices; a streetwise nun from Brooklyn named Sister Robert Anne; Sister Mary Leo, a novice who is a wannabe ballerina; and the delightfully wacky Sister Mary Amnesia, the nun who has lost her memory.